Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 52 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Softgel
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
300 mg
Black Pepper Ext. (Piper nigrum)(fruit)(standardized to contain 95% Piperine)(BioPerine®)
5 mg

Top Medical Research Studies

We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.

To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.

Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.

Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.

Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.

Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.

Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More

Most Useful Reviews

9
Improved heart function
23 people found this helpful
Coenzyme Q10 is vital for energy production and supports heart health. After taking 300 mg daily for a month, I've felt an increase in vitality and improved heart function. Highly recommend Doctor's Best!
Read More
9
Antioxidant benefits
5 people found this helpful
This supplement is crucial for everyone as it may prevent heart disease and improve gum health. CoQ10 production declines after 40, making supplementation necessary. Top quality with no taste or smell.
Read More
9
Youth preservation
4 people found this helpful
I'm pleased with this product; its natural ingredients positively impact my heart and skin. CoQ10 100 mg strengthens the heart, reduces statin side effects, and helps preserve youth.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
  • All Researches
We aimed to investigate the effects of Coenzyme Q10 (CoQ10) on heart health in the context of CDKL5 deficiency disorder (CDD). CDD is a complex condition caused by mutations in the CDKL5 gene, leading to severe developmental challenges and systemic issues, including oxidative stress.

Our study demonstrated that CoQ10 supplementation can significantly reduce harmful levels of reactive oxygen species (ROS) and help restore a balanced state of glutathione in the body. This is important because oxidative stress is believed to contribute to various health problems, including those affecting the heart.

Additionally, we found that CoQ10 not only improved markers of cellular health and proliferation in a human neuron model but also provided protective effects against lipid peroxidation and DNA damage in the hearts of a mouse model of CDD.

Overall, our findings suggest that CoQ10 may play a crucial role in alleviating oxidative stress and protecting heart health in individuals with CDD, offering a potential therapeutic avenue worth exploring further.
Read More
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.

To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.

Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.

Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
Read More
We explored the effectiveness of coenzyme Q10 in treating heart failure by analyzing data from 33 randomized controlled trials. These studies collectively aimed to determine whether coenzyme Q10 could improve outcomes for people suffering from heart disease.

Our findings indicated that coenzyme Q10 helps reduce all-cause mortality and hospitalization rates for heart failure. We saw significant improvements in other health markers as well, such as the New York Heart Association classification, which assesses heart function, and reductions in brain natriuretic peptide levels, a marker of heart stress.

Additionally, participants taking coenzyme Q10 showed improved left ventricular ejection fraction—an important measure of heart efficiency—and performed better on the 6-minute walk test compared to those in the control group. Remarkably, we observed these benefits without any major adverse effects associated with coenzyme Q10 treatment.

Overall, the consistent results from various studies suggest that coenzyme Q10 could be a valuable addition to heart failure management. Our analysis points to its potential to enhance quality of life for individuals living with this challenging condition.
Read More
We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.
Read More
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.

After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.

However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.

Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
Read More

User Reviews

USERS' SCORE
Good
Based on 52 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Improved heart function
23 people found this helpful
Coenzyme Q10 is vital for energy production and supports heart health. After taking 300 mg daily for a month, I've felt an increase in vitality and improved heart function. Highly recommend Doctor's Best!
Read More
9
Antioxidant benefits
5 people found this helpful
This supplement is crucial for everyone as it may prevent heart disease and improve gum health. CoQ10 production declines after 40, making supplementation necessary. Top quality with no taste or smell.
Read More
9
Youth preservation
4 people found this helpful
I'm pleased with this product; its natural ingredients positively impact my heart and skin. CoQ10 100 mg strengthens the heart, reduces statin side effects, and helps preserve youth.
Read More
9
Improved heart health
3 people found this helpful
A wonderful product that benefits heart health. My wife had poor ovarian reserve, and after using it, her health and mood improved significantly.
Read More
9
Migraine relief
3 people found this helpful
CoQ10 stabilises energy levels and is essential for individuals with heart disease or those taking statins. It's beneficial for migraines and has shown significant improvement in their frequency and severity.
Read More

Frequently Asked Questions

8.5
Cardiovascular improvement
4 people found this helpful
At 49, after just four days on CoQ10, I noticed improvements in my endurance and reduced heart-related symptoms. The quality and effectiveness are excellent, and packaging is convenient.
9
Improved heart function
23 people found this helpful
Coenzyme Q10 is vital for energy production and supports heart health. After taking 300 mg daily for a month, I've felt an increase in vitality and improved heart function. Highly recommend Doctor's Best!
9
Affordable quality
3 people found this helpful
With heart disease, my cardiologist recommended 300 mg of CoQ10 daily. This product is priced half compared to others, and the quality is excellent.
9
Improved heart health
1 people found this helpful
I've been using Doctor's Best High Absorption CoQ10 for a few months, and the results are fantastic. The 300 mg dosage effectively supports my heart health, and I feel a notable improvement in my energy levels. The addition of BioPerine® enhances absorption, ensuring I receive the maximum benefits. These veggie softgels are easy to swallow, made with clean ingredients, and free from artificial additives. I've noticed reduced muscle fatigue after exercise, and my cardiovascular health feels stronger. I highly recommend this product for its value and effectiveness.
9
Energy and breathing
1 people found this helpful
I have tried many expensive CoQ10 brands to alleviate muscle pain and weakness from statins, but this one showed results from Day 1. Within half an hour, I felt extra energy and easier breathing, allowing me to run faster. I would recommend it to anyone enduring statin side effects.
9
Improved heart health
3 people found this helpful
A wonderful product that benefits heart health. My wife had poor ovarian reserve, and after using it, her health and mood improved significantly.
8.5
Boosts heart function
5 people found this helpful
Coenzyme Q10 supports heart function and energy production in cells. Factors like stress and age can decrease CoQ10 levels, crucial for energy and muscle work. It aids cardiovascular health and provides energy for those feeling fatigued. It's excellent that this product includes black pepper extract for better absorption.
9
Improved health quality
Excellent product! I highly recommend it. The Omega 3 is great for hair and arthritis, beneficial for heart health, and has a pleasing taste. The quality of the ingredients is outstanding, and it effectively reduces cholesterol. I recommend it for its excellent quality and price.
9
Supports heart health
1 people found this helpful
Excellent coenzyme with black pepper extract for better absorption; it offers a good price/quality ratio. A key supplement for those over 40, Coenzyme Q10 activates mitochondria, aiding energy production and supporting heart health. It also helps combat oxidative stress. The effective dosage is 100 mg per day. Consult your doctor for correct dosing.
8
CoQ10 may improve heart health
We explored how Coenzyme Q10 (CoQ10) combined with ultrasound-targeted microbubble destruction (UTMD) could help treat diabetic cardiomyopathy (DCM) in rats. In our study, we took a close look at the heart health of diabetic rats after using these innovative treatments. Specifically, we used a group of 60 male rats, inducing diabetes in most of them and setting up control groups for comparison.

After treating the rats for 12 weeks, we observed that the group receiving CoQ10 encapsulated in nanoliposomes combined with UTMD showed promising signs of improvement. Notably, their heart structure appeared intact, and they had improved heart function metrics like left ventricular dimensions. We found significant reductions in harmful indicators of heart stress and damage among the treatment group compared to those not receiving the combined therapy.

It's important to mention that while CoQ10 seemed beneficial in this context, the study did not isolate the effects of CoQ10 alone. This means we cannot definitively conclude its exclusive role without considering the combined effect with UTMD. Overall, our findings indicate that CoQ10, especially with the support of advanced delivery techniques, can contribute to better heart health in diabetes-affected conditions.
This study focused on the potential protective effects of Coenzyme Q10 (CoQ10) against heart damage caused by copper toxicity. We induced myocardial injury in rats using daily doses of copper sulfate for a week, observing detrimental effects on heart function.

To assess CoQ10’s effectiveness, we treated the rats with either regular CoQ10 or its liposomal form while they were exposed to copper. The results were encouraging: both forms of CoQ10 showed the ability to reduce signs of heart injury, such as elevated heart muscle enzymes and markers of oxidative stress.

Notably, we observed that these treatments improved the rat's antioxidant capacity and reduced inflammation, key factors associated with heart disease. By downregulating harmful pathways linked to cell death and inflammation, CoQ10 demonstrated its potential as a valuable defense against heart problems arising from copper exposure.

Overall, this research highlights the cardioprotective properties of CoQ10, positioning it as a beneficial supplement for those at risk of copper toxicity and related heart issues.
9
CoQ10 mitigates chemotherapy-related heart damage
We aimed to explore the effects of Coenzyme Q10 (CoQ10) on heart health in the context of Doxorubicin treatment, a common chemotherapy known for its side effects, including heart damage. Our study involved 27 white albino rats, which we divided into three groups: one receiving CoQ10, another receiving Doxorubicin, and a final group receiving both treatments.

After the treatment period, the rats were humanely sacrificed to analyze the condition of their heart and lung tissues. We prepared slides of these tissues for microscopic examination. The results revealed that Doxorubicin exposure led to significant abnormalities in the cellular structures of the heart and lungs, indicating damage caused by the drug.

However, the introduction of CoQ10 appeared to mitigate these negative effects. The CoQ10 treatment helped restore the structure of the tissues, suggesting that it plays a protective role against the damaging impact of Doxorubicin.

Overall, our findings indicate that CoQ10 may be beneficial in maintaining heart health during chemotherapy by counteracting some of the harmful effects posed by Doxorubicin.
7
CoQ10's unclear heart health benefits
We explored the effects of coenzyme Q10 (CoQ10) on heart disease, particularly in relation to diabetic cardiomyopathy, a common complication for those with diabetes. The study discussed various treatment options for heart issues stemming from diabetes, highlighting how CoQ10 might play a role.

While CoQ10 has shown promise in some areas of heart health, the study indicates it does not deliver clear benefits when isolated from other treatments. This suggests that while it may be part of a broader treatment strategy, relying solely on CoQ10 for heart disease management may not be effective.

In addition to CoQ10, we noted the importance of lifestyle changes such as maintaining a healthy diet and engaging in regular physical activity. These factors are crucial in combatting the progression of diabetic cardiomyopathy and improving overall heart health.

References

  1. Loi M, Valenti F, Medici G, Mottolese N, Candini G, et al. Beneficial Antioxidant Effects of Coenzyme Q10 in In Vitro and In Vivo Models of CDKL5 Deficiency Disorder. Int J Mol Sci. 2025;26. 10.3390/ijms26052204
  2. Vučemilović H, Kovač R, Stanišić L, Sanader Vučemilović A, Mrčela D, et al. Is High-Dose Ubiquinone Therapy Before Cardiac Surgery Enough to Reduce the Incidence of Cardiac Surgery-Associated Acute Kidney Injury? A Randomized Controlled Trial. Antioxidants (Basel). 2025;14. 10.3390/antiox14020243
  3. Alghibiwi HK, Alhusiani AM, Sarawi WS, Fadda L, Alomar HA, et al. Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats. Cell Mol Biol (Noisy-le-grand). 2025;71:118. 10.14715/cmb/2025.70.1.13
  4. Zhang M, Sun MY, He WY, Yu SF, Ma WC. [Experimental study on the treatment of diabetic cardiomyopathy in rats by using ultrasound-targeted microbubble destruction combined with coenzyme Q10 loaded long-circulating nanoliposomes]. Zhonghua Yi Xue Za Zhi. 2024;104:3765. 10.3760/cma.j.cn112137-20240605-01273
  5. Xu J, Xiang L, Yin X, Song H, Chen C, et al. Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord. 2024;24:592. 10.1186/s12872-024-04232-z
  6. Guo Z, Tian Y, Liu N, Chen Y, Chen X, et al. Mitochondrial Stress as a Central Player in the Pathogenesis of Hypoxia-Related Myocardial Dysfunction: New Insights. Int J Med Sci. 2024;21:2502. 10.7150/ijms.99359
  7. Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. 10.1080/14796678.2024.2352308
  8. Intan RE, Balti DR, Nugraha RA, Alkaff FF, Salamah S, et al. Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report. J Pak Med Assoc. 2024;74:S81. 10.47391/JPMA.S6-ACSA-16
  9. Ali S, Sulaiman E, Dhiaa S. HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS. Georgian Med News. 2024.
  10. Alehagen U, Aaseth J, Schomburg L, Larsson A, Opstad T, et al. Selenoprotein P increases upon selenium and coenzyme Q supplementation and is associated with telomere length, quality of life and reduced inflammation and mortality. Free Radic Biol Med. 2024;222:403. 10.1016/j.freeradbiomed.2024.06.027
  11. Zeng M, Chen Z, Zhang Y, Pang Y. Combination of trimetazidine and coenzyme Q10 for the treatment of acute viral myocarditis: a systematic review and meta-analysis. J Infect Dev Ctries. 2024;18:658. 10.3855/jidc.18776
  12. Du H, Zhao Y, Wen J, Dai B, Hu G, et al. LncRNA DCRT Protects Against Dilated Cardiomyopathy by Preventing NDUFS2 Alternative Splicing by Binding to PTBP1. Circulation. 2024;150:1030. 10.1161/CIRCULATIONAHA.123.067861
  13. Graczyk P, Dach A, Dyrka K, Pawlik A. Pathophysiology and Advances in the Therapy of Cardiomyopathy in Patients with Diabetes Mellitus. Int J Mol Sci. 2024;25. 10.3390/ijms25095027
  14. Alehagen U, Alexander J, Aaseth JO, Larsson A, Opstad TB. Supplementation with selenium and coenzyme Q in an elderly Swedish population low in selenium - positive effects on thyroid hormones, cardiovascular mortality, and quality of life. BMC Med. 2024;22:191. 10.1186/s12916-024-03411-1
  15. Antar SA, Abdo W, Helal AI, Abduh MS, Hakami ZH, et al. Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice. Life Sci. 2024;348:122688. 10.1016/j.lfs.2024.122688
  16. Seo JS. Chronological change of left ventricular global longitudinal strain in patients with maternally inherited diabetes and deafness: A case series. Medicine (Baltimore). 2024;103:e37447. 10.1097/MD.0000000000037447
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